CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.
Function
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.
Clinical significance
Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.
See also
- Cluster of differentiation
References
Further reading
External links
- CD6 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD6 genome location and CD6 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P30203 (Human T-cell differentiation antigen CD6) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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